Stable gene transfer of CCR5 and CXCR4 siRNAs by sleeping beauty transposon system to confer HIV-1 resistance
Abstract Background Thus far gene therapy strategies for HIV/AIDS have used either conventional retroviral vectors or lentiviral vectors for gene transfer.Although highly efficient, their use poses a certain degree of risk in terms of viral mediated oncogenesis.Sleeping Beauty (SB) transposon system offers a non-viral method of gene transfer to avo